The Best Medicine For Anxiety Disorders SSRIs (selective serotonin reuptake inhibitors) and SNRIs, such as citalopram (Celexa), Escitalopram (Lexapro), the fluoxetine (Prozac), duloxetine (Cymbalta) and venlafaxine (Effexor XR) are considered the first-line treatments for anxiety disorders. Exercise and psychotherapy are essential for those suffering from anxiety. Some doctors prescribe antihistamines